KMID : 0624620140470090483
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BMB Reports 2014 Volume.47 No. 9 p.483 ~ p.487
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TM4SF5-mediated protein-protein networks and tumorigenic roles
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Lee Jung-Weon
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Abstract
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Transmembrane 4 L six family member 5 (TM4SF5), as a membrane glycoprotein with 4 transmembrane domains, is similar to the tetraspanins in terms of membrane topology and plays important roles in tumorigenesis and tumor metastasis. Especially, TM4SF5 appears to form a massive protein-protein complex consisting of diverse membrane proteins and/or receptors in addition to cytosolic signaling molecules to regulate their signaling activities during the pathological processes. TM4SF5 is shown to interact with integrins ¥á2, ¥á5, and ¥â1, EGFR, IL6R, CD151, focal adhesion kinase (FAK), and c-Src. This review focuses on the significance of the interactions with regards to TM4SF5-positive tumorigenesis and metastasis.
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KEYWORD
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Cytokine receptors, EGFR, Fibrosis, Integrins, Metastasis, Tetraspanin, TM4SF5
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